Study attempted to investigate the correlation of psychological symptoms in RA patients with the different parameters of the disease. The sample consisted of 100 patients, including 60 rheumatoid arthritis (RA) patients and 40 patients with osteoarthritis (OA) of the knees as a comparative group, and represented newly diagnosed as well as chronic patients in different classes and stages of the disease. Thorough history taking, examination and investigations were done. The Arabic version of Symptom Check List-90-Revised (SCL-90-R) was used as a part of the psychological and psychiatric assessment of the patients. The findings showed that disability was the RA disease parameter that correlated mostly with depression, followed by the ESR, disease severity, duration, seropositivity and pain were not significantly correlated with any psychological factor. These findings were discussed in the light of the recent literature